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PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

✍ Scribed by Day, Cheryl L.; Kaufmann, Daniel E.; Kiepiela, Photini; Brown, Julia A.; Moodley, Eshia S.; Reddy, Sharon; Mackey, Elizabeth W.; Miller, Joseph D.; Leslie, Alasdair J.; DePierres, Chantal

Book ID
109896152
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
753 KB
Volume
443
Category
Article
ISSN
0028-0836

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## Abstract Excessive immune activation is a hallmark of chronic uncontrolled HIV infection. During the past years, growing evidence suggests that immune inhibitory signals also play an important role in progressive disease. However, the relationship between positive and negative immune signals on