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Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

✍ Scribed by Trautmann, Lydie; Janbazian, Loury; Chomont, Nicolas; Said, Elias A; Gimmig, Sylvain; Bessette, Benoit; Boulassel, Mohamed-Rachid; Delwart, Eric; Sepulveda, Homero; Balderas, Robert S

Book ID: 109932916
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 427 KB
Volume: 12
Category: Article
ISSN: 1078-8956
DOI: 10.1038/nm1482

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## Abstract Excessive immune activation is a hallmark of chronic uncontrolled HIV infection. During the past years, growing evidence suggests that immune inhibitory signals also play an important role in progressive disease. However, the relationship between positive and negative immune signals on