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PCOLCE deletion and expression analyses in uterine leiomyomata

✍ Scribed by Azra H Ligon; Ian C Scott; Kazuhiko Takahara; Daniel S Greenspan; Cynthia C Morton

Book ID
114135357
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
361 KB
Volume
137
Category
Article
ISSN
0165-4608

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The high-mobility-group (HMG) protein gene, HMGIC, is localized to chromosome 12, band q15, a region often rearranged in benign mesenchymal tumors, including uterine leiomyomata. Although some evidence suggests a role in regulation of cell proliferation, the precise function of HMGIC in the developm

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## Abstract The high mobility group gene, __HMGA2__, is frequently expressed in uterine leiomyomata (UL) with chromosomal rearrangements of 12q15. In contrast, __HMGA2__ expression has not been detected in karyotypically normal UL or in myometrium, but has been detected in these tissues after cultu