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PCNA independence of Ki-67 expression in HPV infection.

✍ Scribed by M.E. Boon; C.V. Howard; D van Velzen

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 213 KB
Volume: 17
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.1993.1029

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

12 Infectious Wart lesions were stained using the streptavidin‐biotin immunoperoxidase method for PCNA10, MIB‐1 (Ki‐67 equivalent antigen) and Human Papilloma Virus antigen to study the effect of HPV presence on epidermal proliferation. Using strict methods to avoid observer bias, Ki‐67 antigen was found in a high proportion of nuclei in the suprabasal layers together with HPV antigens, in the absence of PCNA staining. This finding indicates that DNA synthesis related, Ki‐67 antigen bearing structures can be raised in the human nucleus in the absence of induction of PCNA bearing structures, suggesting also structural independence between the antigen bearing molecules.

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