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Patterns of liver iron accumulation in patients with sickle cell disease and thalassemia with iron overload

✍ Scribed by Jane S. Hankins; Matthew P. Smeltzer; M. Beth McCarville; Banu Aygun; Claudia M. Hillenbrand; Russell E. Ware; Mihaela Onciu


Book ID
114794774
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
202 KB
Volume
85
Category
Article
ISSN
0902-4441

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## Abstract Patients with sickle cell disease (SCD) appear to be at lower risk of endocrinopathies and cardiac dysfunction than those with thalassemia major (TM). Circulating redox active iron is lower in these patients, possibly due to increased systemic inflammation and circulating cytokines. Hep

Spleen R2 and R2* in iron-overloaded pat
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## Abstract ## Purpose To evaluate the magnetic properties of the spleen in chronically transfused, iron‐overloaded patients with sickle cell disease (SCD) and thalassemia major (TM) and to compare splenic iron burdens to those in the liver, heart, pancreas, and kidneys. ## Materials and Methods