✦ LIBER ✦

Pattern of second primary neoplasms following breast cancer

✍ Scribed by Parikh, Bhavna; Advani, Suresh

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 285 KB
Volume: 63
Category: Article
ISSN: 0022-4790
DOI: 10.1002/(sici)1096-9098(199611)63:3<179::aid-jso8>3.0.co;2-a

No coin nor oath required. For personal study only.

✦ Synopsis

Background: Second primary neoplasms (SPN) have been seen with diseases such as breast cancer and Hodgkin's disease. Therapeutic agents used for their treatment have been found responsible for the development of SPN in some cases. In addition, genetic factors are known to contribute to their development.

Methods:

A retrospective study of 15 patients who had primary breast cancer and developed SPN concurrently or sequentially was conducted. Results: Of 15 patients analysed in this study, five had haematological SPN, four had ovarian cancer, and six had different types of non-haematological SPN. Familial clustering was found in two patients. A peculiar abnormality of chromosome 5 and 7 was detected in one patient with haematological SPN, suggesting therapy-related leukeamia. Conclusions: It is postulated that alkylating agents with or without pS3 gene inactivation may predispose to leukaemia, whereas ovarian tumours following breast cancer could be related to BRCA 1 gene inactivation.

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