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Pattern of chromosomal imbalances in non-B virus related hepatocellular carcinoma detected by comparative genomic hybridization

✍ Scribed by M.A Collonge-Rame; S Bresson-Hadni; S Koch; J.P Carbillet; O Blagosklonova; G Mantion; J.P Miguet; B Heyd; J.L Bresson

Book ID
114135041
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
80 KB
Volume
127
Category
Article
ISSN
0165-4608

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Comparative genomic hybridization (CGH) was used to evaluate and map genomic aberrations in 50 hepatocellular carcinomas (HCCs) from patients chronically infected with hepatitis B virus (HBV). CGH clearly detected nonrandom genomic imbalances. Losses were most prevalent on chromosome regions 4q (70%