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Chromosomal changes in fibrolamellar hepatocellular carcinoma detected by array comparative genomic hybridization

✍ Scribed by Kakar, Sanjay; Chen, Xin; Ho, Coral; Burgart, Lawrence J; Sahai, Vaibhav; Dachrut, Somkid; Yabes, Annoel; Jain, Dhanpat; Ferrell, Linda D

Book ID
109887605
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
268 KB
Volume
22
Category
Article
ISSN
0893-3952

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Comparative genomic hybridization (CGH) was used to evaluate and map genomic aberrations in 50 hepatocellular carcinomas (HCCs) from patients chronically infected with hepatitis B virus (HBV). CGH clearly detected nonrandom genomic imbalances. Losses were most prevalent on chromosome regions 4q (70%