𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pattern ERG in rats following section of the optic nerve

✍ Scribed by N. Berardi; L. Domenici; A. Gravina; L. Maffei

Publisher
Springer-Verlag
Year
1990
Tongue
English
Weight
717 KB
Volume
79
Category
Article
ISSN
0014-4819

No coin nor oath required. For personal study only.

✦ Synopsis

The aim of this study is to investigate in the rat the properties of the pattern electroretinogram (ERG) and to assess whether it depends upon the functional integrity of ganglion cells. Flash and pattern ERG were recorded from urethane anaesthetized hooded rats. The pattern ERG was evoked by phase alternating gratings of various spatial frequencies and contrasts. In the first part of the study we determined how the amplitude of the main harmonic of the pattern ERG (2nd harmonic) varies as a function of stimulus parameters such as spatial and temporal frequency, contrast and mean luminance. In the second part of the study we investigated the effects of the retrograde degeneration of ganglion cells following optic nerve section on the amplitude of pattern ERG. We found that the section of the optic nerve leads to the progressive disappearance of the P-ERG which is almost complete 4 months after surgery. By this time only few axotomized ganglion cells are left. The flash ERG remained unaffected. Thus, the pattern electroretinogram seems to be a simple and sensitive tool to investigate the functional integrity of retinal ganglion cells in rats.

πŸ“œ SIMILAR VOLUMES

The pattern evoked response in disorders
The pattern evoked response in disorders of the optic nerve
✍ N. R. Galloway; J. Tolia; C. Barber πŸ“‚ Article πŸ“… 1986 πŸ› Springer-Verlag 🌐 English βš– 186 KB

The pattern evoked electroretinogram (PERG) was investigated in 11 patients with unilateral optic nerve disease and in a series of age-matched controls. The visually evoked potential (VEP) was also measured. The PERG showed a similar reduction to the VEP in optic nerve disease. Serial studies indica

Clinical study of the pattern electroret
Clinical study of the pattern electroretinogram in patients with optic nerve damage
✍ Yukihiko Mashima; Yoshihisa Oguchi πŸ“‚ Article πŸ“… 1985 πŸ› Springer-Verlag 🌐 English βš– 273 KB

We have recorded both pattern and flash electroretinograms (ERG) in two patients with unilateral optic nerve damage due to optic canal fracture over one year. The pattern ERG from the affected eye was reduced in amplitude by approximately 40% in one patient, 60% in the other, compared with that from

Manganese-enhanced MRI of the optic visu
Manganese-enhanced MRI of the optic visual pathway and optic nerve injury in adult rats
✍ Marte Thuen; Trond E. Singstad; Tina Bugge Pedersen; Olav Haraldseth; Martin Ber πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 706 KB

## Abstract ## Purpose To evaluate manganese (Mn^2+^)‐enhanced MRI in a longitudinal study of normal and injured rat visual projections. ## Materials and Methods MRI was performed 24 hours after unilateral intravitreal injection of MnCl~2~ (150 nmol) into adult Fischer rats that were divided int

Effect of neonatal capsaicin and infraor
Effect of neonatal capsaicin and infraorbital nerve section on whisker-related patterns in the rat trigeminal nucleus
✍ Waite, Phil M.E.; de Permentier, Patrick J. πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 991 KB

In the present study, we investigated the effect of neonatally administered capsaicin on whisker-related pattern formation in the rat trigeminal complex. Both normal whiskerrelated patterns of barrelettes and the modified patterns seen after neonatal section of the infraorbital nerve were assessed.