Patient with chronic myelogenous leukemia and late appearing Philadelphia chromosome
✍ Scribed by Rubén Lisker; Lourdes Casas; Osvaldo Mutchinick; Benjamín López-Ariza; Juan Labardini
- Book ID
- 119102621
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 293 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0165-4608
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## Abstract ## BACKGROUND Anecdotal cases of chromosomal abnormalities in Philadelphia chromosome (Ph)‐negative metaphases have been reported in patients with chronic myelogenous leukemia (CML) in the chronic phase during treatment with interferon and, more recently, with imatinib. This phenomenon
## Abstract ## BACKGROUND. The prognosis of patients with chronic myelogenous leukemia (CML) after failure of imatinib mesylate therapy is not well documented. ## METHODS. The outcome of 420 patients with CML post‐imatinib failure (resistance‐recurrence in 374; toxicities in 46) were reviewed in