✦ LIBER ✦

Patient versus informant reported quality of life in the earliest phases of Alzheimer's disease

✍ Scribed by Asmus Vogel; Erik Lykke Mortensen; Steen G. Hasselbalch; Birgitte B. Andersen; Gunhild Waldemar

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 95 KB
Volume: 21
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.1619

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objectives

The study investigated if patient and informant reported Quality of Life (QoL) differed in early Alzheimer's disease (AD). In addition, we examined whether anosognosia had an impact on the agreement between patient and informant ratings of QoL and whether anosognosia, dementia severity, depression and behavioural symptoms were significantly correlated to QoL in early AD.

Methods

From a prospective research program including newly referred patients (age >60 years and MMSE ≥ 20), 48 patients with very early AD were included. QoL was assessed using the QoL‐AD and EQ‐5D scales. Anosognosia was rated on a categorical scale by an examiner. MMSE, Geriatric Depression Scale, Danish Adult Reading Test and Frontal Behavioural Inventory were also administered.

Results

On most QoL measures patients rated their QoL higher than their informants. Anosognosia was not associated with QoL but significantly with an inverse impact on the agreement between patient and informant ratings of QoL. Self‐reported QoL was significantly correlated to depression but not to age, dementia severity, behavioural symptoms or memory impairment. Informant ratings of QoL were significantly correlated to behavioural symptoms and informant ratings on the EQ‐5D Visual Analogue Scale were significantly correlated to patient reported depression.

Conclusion

Patients with early AD generally reported higher QoL than their informants. This disagreement was associated with the presence of anosognosia. Self‐reported QoL did not correlate with the MMSE score. Behavioural changes and depressive symptoms may be associated with low QoL. Copyright © 2006 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Patient versus informant perspectives of

Patient versus informant perspectives of Quality of Life in Mild Cognitive Impairment and Alzheimer's disease

✍ Rebecca E. Ready; Brian R. Ott; Janet Grace 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB 👁 2 views

## Abstract ## Background Prior studies on Quality of Life (QOL) in Alzheimer's disease (AD) have rarely included control participants, or participants with very mild levels of cognitive impairment. Furthermore, there is little data to indicate whether or not mildly impaired patients can provide s

Assessing quality of life in Taiwanese p

Assessing quality of life in Taiwanese patients with Alzheimer's disease

✍ Jong-Ling Fuh; Shuu-Jiun Wang 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 64 KB 👁 2 views

Objective To measure differences in patients with Alzheimer's disease (AD) and caregiver assessments of the patients' quality of life (QOL) and to identify the patient characteristics, caregiver characteristics, or patient-caregiver interactions responsible for these differences. Methods We recruite

Neuropsychiatric symptoms and Quality of

Neuropsychiatric symptoms and Quality of Life in patients with very mild and mild Alzheimer's disease

✍ Kristiina Karttunen; Pertti Karppi; Asta Hiltunen; Matti Vanhanen; Tarja Välimäk 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 156 KB 👁 2 views

Background: Neuropsychiatric symptoms (NPS) are common manifestations of Alzheimer' s disease (AD). Objective: To examine the prevalence and significance of NPS in very mild and mild AD patients with emphasis on their influence on the well-being of the patients and their caregivers. Methods: The par

Proxy reports in Parkinson's disease: Ca

Proxy reports in Parkinson's disease: Caregiver and patient self-reports of quality of life and physical activity

✍ Allison Fleming; Karon F. Cook; Naomi D. Nelson; Eugene C. Lai 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB

## Abstract We evaluated patient–proxy agreement in a population of veterans with Parkinson's disease and compared levels of agreement by patient subgroups. Patient and caregiver pairs completed questionnaires composed of standard measures and additional demographic and activity questions. Particip

Factors related to perceived quality of

✍ Josep Lluís Conde-Sala; Josep Garre-Olmo; Oriol Turró-Garriga; Secundino López-P 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 103 KB 👁 2 views

## Abstract ## Aims To compare care recipient and caregiver perceptions of quality of life in patients (QoL‐p) with Alzheimer's disease (AD). To identify associated factors, and the concordances‐discrepancies. ## Method Cross‐sectional analytic study of 236 patients and their carers using the Qu

Assessing the relationship between healt

Assessing the relationship between health utilities, quality of life, and health services use in Alzheimer's disease

✍ Edward Alan Miller; Lon S. Schneider; Robert A. Rosenheck 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 102 KB 👁 2 views

## Abstract ## Objectives To examine the relationship between use of multiple health services and health utilities, quality of life and other factors in Alzheimer's disease (AD). ## Design Data were obtained via caregiver proxy at baseline and 3‐ 6‐ and 9‐months post‐random assignment among 421