✦ LIBER ✦

Patient versus informant perspectives of Quality of Life in Mild Cognitive Impairment and Alzheimer's disease

✍ Scribed by Rebecca E. Ready; Brian R. Ott; Janet Grace

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 101 KB
Volume: 19
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.1075

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Prior studies on Quality of Life (QOL) in Alzheimer's disease (AD) have rarely included control participants, or participants with very mild levels of cognitive impairment. Furthermore, there is little data to indicate whether or not mildly impaired patients can provide self‐report QOL data or if informant reports are needed.

Objectives

This study compared QOL ratings from informants and patients with mild AD (n = 26), Mild Cognitive Impairment (MCI, n = 30), and elderly controls (n = 23).

Methods

Participants (aged 60–91 years) were recruited from an outpatient memory disorder clinic. Elderly controls were recruited from the community. Measures about patients were the Dementia Quality of Life scale, the Neuropsychiatric Inventory—Questionnaire, Instrumental of Activities of Daily Living, and Mini‐mental State Exam. Informant depression was assessed with the Geriatric Depression Scale.

Results

Results indicated that overall patient‐informant agreement for MCI (M=0.24), AD (M=0.48), and controls (M=0.49) did not differ significantly. Self‐reported QOL did not differ significantly across the 3 groups. For caregiver‐reports, QOL in MCI again did not differ from controls but was significantly greater than QOL in AD for 2 of 6 scales, and QOL in controls was greater than AD for 4 of 6 scales. Regression analyses indicated that neuropsychiatric symptoms were the most consistent predictors of QOL.

Conclusions

In summary, informant‐ and self‐perceptions of QOL differed substantially. Results suggest that future investigators should carefully consider gathering QOL information from both informants and patients because they provide unique information regarding patient QOL and, to date, neither source of information has been established to be superior. Copyright © 2004 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Patient versus informant reported qualit

Patient versus informant reported quality of life in the earliest phases of Alzheimer's disease

✍ Asmus Vogel; Erik Lykke Mortensen; Steen G. Hasselbalch; Birgitte B. Andersen; G 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB 👁 1 views

## Abstract ## Objectives The study investigated if patient and informant reported Quality of Life (QoL) differed in early Alzheimer's disease (AD). In addition, we examined whether anosognosia had an impact on the agreement between patient and informant ratings of QoL and whether anosognosia, dem

Neuropsychiatric symptoms and Quality of

Neuropsychiatric symptoms and Quality of Life in patients with very mild and mild Alzheimer's disease

✍ Kristiina Karttunen; Pertti Karppi; Asta Hiltunen; Matti Vanhanen; Tarja Välimäk 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 156 KB 👁 2 views

Background: Neuropsychiatric symptoms (NPS) are common manifestations of Alzheimer' s disease (AD). Objective: To examine the prevalence and significance of NPS in very mild and mild AD patients with emphasis on their influence on the well-being of the patients and their caregivers. Methods: The par

Anxiety and behavioural disturbance as m

Anxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment

✍ Damien Gallagher; Robert Coen; Dana Kilroy; Kate Belinski; Irene Bruce; Davis Co 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB 👁 1 views

Depression and anxiety have been reported to be independently predictive of conversion to Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI). Anxiety symptoms have been less well studied and findings in this regard have been inconsistent. The objectives of this study are to de

Assessing quality of life in Taiwanese p

Assessing quality of life in Taiwanese patients with Alzheimer's disease

✍ Jong-Ling Fuh; Shuu-Jiun Wang 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 64 KB 👁 2 views

Objective To measure differences in patients with Alzheimer's disease (AD) and caregiver assessments of the patients' quality of life (QOL) and to identify the patient characteristics, caregiver characteristics, or patient-caregiver interactions responsible for these differences. Methods We recruite

The Apathy Inventory: assessment of apat

The Apathy Inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment

✍ P. H. Robert; S. Clairet; M. Benoit; J. Koutaich; C. Bertogliati; O. Tible; H. C 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB 👁 1 views

## Abstract ## Objective This study was designed to establish the validity and reliability of the apathy inventory (IA), a rating scale for global assessment of apathy and separate assessment of emotional blunting, lack of initiative, and lack of interest. ## Method Information for the IA can be

Detecting prodromal Alzheimer's disease

Detecting prodromal Alzheimer's disease in mild cognitive impairment: utility of the CAMCOG and other neuropsychological predictors

✍ Damien Gallagher; Aine Ni Mhaolain; Robert Coen; Cathal Walsh; Dana Kilroy; Kate 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 169 KB 👁 1 views

## Abstract ## Background The Cambridge cognitive examination (CAMCOG) is a mini neuropsychological battery which is well established and widely used. The utility of the CAMCOG in detecting prodromal Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI) has not been determined.