Pathway-Based Approaches for Analysis of Genomewide Association Studies
β Scribed by Kai Wang; Mingyao Li; Maja Bucan
- Book ID
- 117855277
- Publisher
- American Society of Human Genetics
- Year
- 2007
- Tongue
- English
- Weight
- 250 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/522374
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The detection of loci contributing effects to complex human traits, and their subsequent fine-mapping for the location of causal variants, remains a considerable challenge for the genetics research community. Meta-analyses of genomewide association studies, primarily ascertained from European-descen
## Abstract Many complex diseases are influenced by genetic variations in multiple genes, each with only a small marginal effect on disease susceptibility. Pathway analysis, which identifies biological pathways associated with disease outcome, has become increasingly popular for genomeβwide associa