The question of what significance threshold is appropriate for genomewide association studies is somewhat unresolved. Previous theoretical suggestions have yet to be validated in practice, whereas permutation testing does not resolve a discrepancy between the genomewide multiplicity of the experimen
✦ LIBER ✦
Family-Based Association Tests for Genomewide Association Scans
✍ Scribed by Wei-Min Chen; Gonçalo R. Abecasis
- Book ID
- 117855266
- Publisher
- American Society of Human Genetics
- Year
- 2007
- Tongue
- English
- Weight
- 564 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/521580
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## Abstract Family‐based study designs have an important role in the search for association between disease phenotypes and genetic markers. Unlike traditional case‐control methods, family‐based tests use within‐family data to avoid identification of spurious associations that may result from popula
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