Pathologies of Calcium Channels

✍ Scribed by Daniela Pietrobon (auth.), Norbert Weiss, Alexandra Koschak (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2014
• Tongue: English
• Leaves: 725
• Edition: 1
• Category: Library

✦ Synopsis

Calcium ions represent Mother Nature’s ‘ion-of-choice’ for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies.

Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.

✦ Table of Contents

Front Matter....Pages i-xviii
Front Matter....Pages 1-1
Ca v 2.1 Channels and Migraine....Pages 3-25
Ataxia and CACNA1A : Episodic or Progressive?....Pages 27-45
Role of L-Type Ca 2+ Channels in Sensory Cells....Pages 47-75
T-Type Calcium Channels and Epilepsy....Pages 77-96
The Involvement of Calcium Channel α 2 δ Subunits in Diseases and as a Therapeutic Target....Pages 97-114
T-Type Calcium Channels in Pain Neuronal Circuits....Pages 115-133
Ca v 1.1 Channel and Hypokalemic Periodic Paralysis....Pages 135-149
Ca v 1.1 in Malignant Hyperthermia....Pages 151-165
Ryanodine Receptor 1 and Associated Pathologies....Pages 167-187
The Lambert-Eaton Myasthenic Syndrome....Pages 189-204
Alternative Exon Effect on Phenotype of Ca v 1.2 Channelopathy: Implications in Timothy Syndrome....Pages 205-224
Brugada Syndrome and Voltage-Gated Calcium Channels....Pages 225-238
Ca v 1.3 Channels and Sino-Atrial Node Dysfunction....Pages 239-254
Auxiliary β-Subunits of L-Type Ca 2+ Channels in Heart Failure....Pages 255-275
Epigenetic, Genetic, and Acquired Regulation of Ca v 3 T-Type Calcium Channel Expression and Function in Tumor Growth and Progression....Pages 277-295
Pharmacology of Voltage-Gated Calcium Channels in Clinic....Pages 297-314
Front Matter....Pages 315-315
TRPM1 and Congenital Stationary Night Blindness....Pages 317-331
Alterations in TRPM2 and TRPM7 Functions in the Immune System Could Confer Susceptibility to Neurodegeneration....Pages 333-363
TRPML Channels and Mucolipidosis Type IV....Pages 365-379
Transient Receptor Potential Channels and Pain....Pages 381-411
Front Matter....Pages 315-315
Hereditary Channelopathies Caused by TRPV4 Mutations....Pages 413-440
TRPC Channels in Cardiac Hypertrophy....Pages 441-462
Role of TRPC and Orai Channels in Vascular Remodeling....Pages 463-490
TRPP2 in Polycystic Kidney Disease....Pages 491-522
TRPM6 and Hypomagnesaemia/Hypocalcaemia....Pages 523-531
TRP Channels in Prostate Cancer....Pages 533-547
Pharmacology of TRPV Channels....Pages 549-575
Front Matter....Pages 577-577
IP 3 Receptors in Neurodegenerative Disorders: Spinocerebellar Ataxias and Huntington’s and Alzheimer’s Diseases....Pages 579-600
RyR2 in Cardiac Disorders....Pages 601-614
P2X Receptors and Pain....Pages 615-633
P2X7 in Bipolar and Depressive Disorders....Pages 635-661
Targeting NMDA Receptors in Epilepsy....Pages 663-693
Nicotinic AChR in Congenital Myasthenic Syndromes....Pages 695-711
CatSper in Male Infertility....Pages 713-728
Back Matter....Pages 729-731

✦ Subjects

Human Physiology; Receptors; Neurochemistry; Internal Medicine