Modulation of Presynaptic Calcium Channels

✍ Scribed by Sumiko Mochida (auth.), Gary Stephens, Sumiko Mochida (eds.)

Publisher: Springer Netherlands
Year: 2013
Tongue: English
Leaves: 368
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book will bring together leading international experts to discuss recent advances in basic scientific knowledge regarding the regulation of presynaptic Ca2+ channels. Importantly, Ca2+ channels represent one of the most widely modulated proteins in the body, being the target of a range of effector pathways and drugs; this range will be fully represented here. A number of therapeutic drugs target the Ca2+ channel complex, including the anti-epileptic gabapentinoid and analgesic ziconotide drugs and the pharmaceutical industry is searching for Ca2+ channel blocking drugs, particularly in the pain, epilepsy, ataxia and migraine areas. Such potential future therapies will be discussed here. Scientific disciplines will focus on electrophysiological studies, but will extend to neuroscience, genetics and biochemical areas. The work described will represent advances at the cutting edge of current neuroscience research and is timely and highly appropriate for the Springer book series.

✦ Table of Contents

Front Matter....Pages i-xii
Front Matter....Pages 1-1
Overview: Spatial and Temporal Regulation of Ca 2+ Channels....Pages 3-26
Front Matter....Pages 27-27
Neuronal Functions of Auxiliary Calcium Channel Subunits....Pages 29-59
Reciprocal Regulation of Neuronal Calcium Channels by Synaptic Proteins....Pages 61-78
Molecular Architecture of Ca 2+ Channel Complexes Organized by Ca V β Subunits in Presynaptic Active Zones....Pages 79-99
Control of Ca V 2 Calcium Channels and Neurosecretion by Heterotrimeric G Protein Coupled Receptors....Pages 101-130
RGK Small GTPases and Regulation of Ca V 2 Channels....Pages 131-149
Protein Interaction Partners of Ca v 2.3 R-Type Voltage-Gated Calcium Channels....Pages 151-174
Voltage-Gated Calcium Channel Signaling to the Nucleus....Pages 175-198
Front Matter....Pages 199-199
Presynaptic Ca 2+ Influx and Its Modulation at Auditory Calyceal Terminals....Pages 201-221
Use of Synthetic Ca 2+ Channel Peptides to Study Presynaptic Function....Pages 223-240
Front Matter....Pages 241-241
Impact of a Loss-of-Function P/Q Type Ca 2+ Channel Mutation on Excitatory Synaptic Control of Cerebellar Purkinje Neurons....Pages 243-261
Ca V 2.1 (P/Q) Voltage Activated Ca 2+ Channels and Synaptic Transmission in Genetic and Autoimmune Diseases....Pages 263-288
Splicing and Editing to Customize Ca V Channel Structures for Optimal Neural Function....Pages 289-318
Presynaptic Calcium Channels as Drug Targets for Pain....Pages 319-343
Sensory Pathway Modulation by Calcium Channel α 2 δ 1 Subunit....Pages 345-362
Back Matter....Pages 363-365

✦ Subjects

Biomedicine general; Neurobiology; Membrane Biology; Cell Physiology

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