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Pathological Phosphorylation Causes Neuronal Death: Effect of Okadaic Acid in Primary Culture of Cerebellar Granule Cells

✍ Scribed by Paola Candeo; Marco Favaron; Imre Lengyel; Radmila M. Manev; Joseph M. Rimland; Hari Manev

Book ID: 111176464
Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 656 KB
Volume: 59
Category: Article
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.1992.tb08474.x

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## Abstract Palytoxin (PTX) is a potent marine phycotoxin that binds to the Na,K‐ATPase, converting this pump into an open channel. We have recently shown (Vale et al., 2006) that PTX causes an irreversible increase in the cytosolic calcium concentration ([Ca^2+^]~c~) in primary cultures of cerebel