Pathogenetic significance of aberrant glycosylation of IgA1 in IgA nephropathy
β Scribed by Ichiei Narita; Fumitake Gejyo
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 348 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1342-1751
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π SIMILAR VOLUMES
## Abstract Diagnostic analysis of clinical markers including serum IgA levels and serum IgA/C3 ratio in patients with IgA nephropathy is described. One hundred patients with IgA nephropathy (IgA nephropathy group) and 100 patients with other primary glomerular diseases (nonβIgA nephropathy group)
The mechanism of mesangial IgA deposition is poorly understood in IgA nephropathy (IgAN). Abnormal glycosylation of carbohydrate moieties in the hinge region of the IgA molecule has recently attracted much attention. In this report, we studied galactosylation and sialylation profiles in ΞΊand Ξ»-IgA 1