Contribution of macromolecular IgA1to IgA abnormality in IgA nephropathy
β Scribed by T. Ito; S. Waga; H. Tanaka; T. Tateyama; M. Yokoyama
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 79 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0931-041X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A test was set up to analyze the direct binding of serum IgA to the lectin jacalin. Under the testing conditions, jacalin bound to both IgA subclasses and reacted similarly with monomeric and polymeric IgA. A jacalin index was defined to quantify serum IgA binding to this lectin. The ja
The mechanism of mesangial IgA deposition is poorly understood in IgA nephropathy (IgAN). Abnormal glycosylation of carbohydrate moieties in the hinge region of the IgA molecule has recently attracted much attention. In this report, we studied galactosylation and sialylation profiles in ΞΊand Ξ»-IgA 1