Pathobiodynamics: Reduction in hepatic and intestinal ligandin (glutathione-S-transferase) levels in rats with severe acute and chronic inflammation

Alterations in hepatic and renal levels

Alterations in hepatic and renal levels of glutathione and activities of glutathione S-transferases from rats treated with cis-dichlorodiamminelatinum-II

✍ Charles L. Litterst; Samuel Tong; Yoichiro Hirokata; Zahid H. Siddik 📂 Article 📅 1982 🏛 Springer 🌐 English ⚖ 442 KB

Adult female rats were treated intraperitoneally with 8 mg/kg of cis-dichlorodiammineplatinum(II). At various times after treatment 1, 3, 5, 8, 12 days replicate animals were killed and liver and kidney cytosols examined for activity of glutathione-dependent transferase activities and levels of glut