## Abstract Because melatonin mimics the effects of microtubular disruptive agents (e.g., colchicine) in various cellular systems, we have examined its effect on water transport in the toad urinary bladder. Microtubules are essential to vasopressinβstimulated water transport in this tissue and are
Path of bulk water movement through the urinary bladder of the toad
β Scribed by Mortimer M. Civan
- Publisher
- Elsevier Science
- Year
- 1970
- Tongue
- English
- Weight
- 258 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0022-5193
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β¦ Synopsis
Vasopressin increases bulk water flow across the toad bladder. To resolve whether this flow proceeds primarily between or through the surface epithelial ceils, the maximum intercellular flow rate was calculated. Since the experimental flow rate is 28 times the calculated maximum, bulk water flow is likely to proceed largely through the cells of the mucosal epithelium.
π SIMILAR VOLUMES
Metabolic control reactions have been studied in the intact toad bladder by means of fluorescence spectrophotometric measurement of reduced pyridine nucleotide and by measurement of respiration with the platinum electrode. Substrates such as pyruvate and succinate lead to prompt increases in reducti