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Melatonin inhibition of vasopressin-stimulated water transport in the toad urinary bladder

✍ Scribed by Haswell, M. Stephen ;Gern, William A. ;Ralph, Charles L.

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
224 KB
Volume
211
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

Because melatonin mimics the effects of microtubular disruptive agents (e.g., colchicine) in various cellular systems, we have examined its effect on water transport in the toad urinary bladder. Microtubules are essential to vasopressin‐stimulated water transport in this tissue and are labile to colchicine (Kachadorian et al., '79). In unstimulated urinary bladders, melatonin is without effect; however, in the presence of 20 ΞΌ/ml of vasopressin, 4 Γ— 10^βˆ’6^M melatonin significantly reduced the stimulation of water transport in this preparation. The inhibition of water transport by melatonin is comparable to that effected by colchicine. The possibility that melatonin may modulate microtubular functions is discussed.

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