Evidence for involvement of microtubules in the action of vasopressin in toad urinary bladder
β Scribed by Leslie Wilson; Ann Taylor
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 755 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-2631
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## Abstract Because melatonin mimics the effects of microtubular disruptive agents (e.g., colchicine) in various cellular systems, we have examined its effect on water transport in the toad urinary bladder. Microtubules are essential to vasopressinβstimulated water transport in this tissue and are
Vasopressin-stimulated cyclic AMP content and the uptake of Hz 0 and 22 Na into canine renal medullary slices were measured. Cyclic AMP was increased threefold by 9 X lO-'M vasopressin in isotonic (290 mOsm/kg HzO) Krebs-Ringers bicarbonate. A significant increase in vasopressin-stimulated Hz 0 upta