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Paternity testing 3: Exclusion probabilities

✍ Scribed by Brown, Constance M. ;Seber, G. A. F. ;Opitz, John M. ;Reynolds, James F.

Book ID
102700705
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
683 KB
Volume
26
Category
Article
ISSN
0148-7299

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✦ Synopsis

Blood typing with several blood systems is used in many countries to determine paternity or nonpaternity with respect to an alleged father. Various probabilities are usually presented, in particular: 1) the conditional probability of excluding a random man as father given a particular mother-child phenotype combination, and 2 ) the expected (unconditional) exclusion probability for all mother-child combinations can be calculated for a given blood system. Because these probabilities are of general interest in paternity studies, explicit formulae for the unconditional probabilities have been derived for some of the systems. Algorithms suitable for a microcomputer are given here for finding the exclusion probabilities for any system. These algorithms avoid the need for developing new formulae whenever a new system is introduced or a current system is extended through the addition of further alleles.

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## Abstract Paternity exclusions are known to be common in Western countries and are yet neglected in segregation analysis because it is almost impossible to check it systematically on a large family sample. We had the opportunity of observing the sensitivity of segregation analysis parameters to a