Sensitivity of transmission probabilities to paternity exclusion in segregation analysis

✍ Scribed by Dr. Catherine Bonaïti-pellié; Nicole Poisson; Yvette Bechtel; Pierre Bechtel; G. P. Vogler

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 323 KB
• Volume: 9
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370090108

✦ Synopsis

Abstract

Paternity exclusions are known to be common in Western countries and are yet neglected in segregation analysis because it is almost impossible to check it systematically on a large family sample. We had the opportunity of observing the sensitivity of segregation analysis parameters to a paternity exclusion in analyzing 34 families for a simple Mendelian trait, the acetylator phenotype. We found that only one family, with proven paternity exclusion, was responsible for a strong rejection of Mendelian transmission probabilities (P≪0.001). © 1992 Wiley‐Liss, Inc.