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Paternal age and Down's syndrome genotypes diagnosed prenatally: No association in New York State data

✍ Scribed by Ernest B. Hook; Philip K. Cross


Publisher
Springer
Year
1982
Tongue
English
Weight
756 KB
Volume
62
Category
Article
ISSN
0340-6717

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From prenatal diagnosis data obtained on mothers aged 35 years and above in the Federal Republic of Germany (DFG data), older fathers are demonstrated to have an increased risk of having trisomy 21 offspring. For paternal ages of 41 years upward, the age effect is quite strong. The risk for a fetus

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The incidence of Down syndrome (DS) at conception is highly dependent on the maternal age distribution and age-specific pregnancy rates. The live birth prevalence of DS reflects these factors and fetal deaths. This study examined DS live birth prevalence from 1983 to 1992 in New York State and analy