✦ LIBER ✦

Paternal age and Down's syndrome data from prenatal diagnoses (DFG)

✍ Scribed by J. Stene; E. Stene; S. Stengel-Rutkowski; J. -D. Murken

Publisher: Springer
Year: 1981
Tongue: English
Weight: 548 KB
Volume: 59
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00293059

No coin nor oath required. For personal study only.

✦ Synopsis

From prenatal diagnosis data obtained on mothers aged 35 years and above in the Federal Republic of Germany (DFG data), older fathers are demonstrated to have an increased risk of having trisomy 21 offspring. For paternal ages of 41 years upward, the age effect is quite strong. The risk for a fetus to have any de novo chromosomal aberration increases more with advancing paternal age for older mothers than for younger ones. Thus the ages of both parents have to be taken into account as an indication for prenatal diagnosis. Risk figures for trisomy 21 and for any de novo chromosomal aberration are given, together with preliminary recommendations for prenatal diagnosis for different combinations of parental ages.

📜 SIMILAR VOLUMES

Paternal age and Down's syndrome genotyp

Paternal age and Down's syndrome genotypes diagnosed prenatally: No association in New York State data

✍ Ernest B. Hook; Philip K. Cross 📂 Article 📅 1982 🏛 Springer 🌐 English ⚖ 756 KB

A reanalysis of the New York State prena

A reanalysis of the New York State prenatal diagnosis data on Down's syndrome and paternal age effects

✍ Eeva Stene; Jon Stene; Sabine Stengel-Rutkowski 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 430 KB

Down syndrome and paternal age, a new an

Down syndrome and paternal age, a new analysis of case–control data collected in the 1960s

✍ Elizabeth De Souza; Eva Alberman; Joan K. Morris 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 84 KB 👁 3 views

Issues in analysis of data on paternal a

Issues in analysis of data on paternal age and 47,+21: implications for genetic counseling for Down syndrome

✍ Ernest B. Hook 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 452 KB

An analysis of paternal age and 47,+21 i

An analysis of paternal age and 47,+21 in 35,000 new prenatal cytogenetic diagnosis data from the New York State Chromosome Registry: no significant effect

✍ Philip K. Cross; Ernest B. Hook 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 569 KB

The effect of differences in the distrib

The effect of differences in the distribution of maternal age in England and Wales on the performance of prenatal screening for Down's syndrome

✍ T. Huang; H. C. Watt; N. J. Wald 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB 👁 3 views

We aimed to determine how differences in the age at which women had their pregnancies influenced the expected detection and false-positive rates of serum screening for Down 's syndrome (i) between 1970 and 1993 in England and Wales, and (ii) between regions and districts of England and Wales in 1991