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Passive protection of mice, goats, and monkeys against Japanese encephalitis with monoclonal antibodies

✍ Scribed by Mingjie Zhang; Meixan Wang; Shaozhun Jiang; Wenyu Ma

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
536 KB
Volume
29
Category
Article
ISSN
0146-6615

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✦ Synopsis

Six monoclonal antibodies (McAbs) against Japanese encephalitis virus (JEV) were tested for passive protection in JEV-infected mice, goats, and rhesus monkeys. mG9 and nG2 had no protective effect; mG3 and 2D2 had some protective effect, but not sufficient to be of therapeutic significance; and 2H4 and 2F2 had excellent protective efficacy in mice even 120 hr after infection when most of the mice in the virus control group were sick. The mixture of 2H4, 2F2, mC3 (M-McAb), and their F(ab')2 fragments showed excellent protection in mice, goats, and monkeys and was safe. The protective effects of McAbs correlated with their neutralization titers, but cytotoxicity-mediated activities also played a role in protection.

πŸ“œ SIMILAR VOLUMES

Laboratory diagnosis of japanese encepha
Laboratory diagnosis of japanese encephalitis using monoclonal antibodies and correlation of findings with the outcome
✍ Dr. V. Ravi; S. Vanajakshi; Anke Gowda; A. Chandramuki πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 285 KB

Detection of virus, viral antigen, and class-specific antibody was carried out in cerebrospinal fluid (CSF) and sera of 27 children with Japanese encephalitis. The diagnosis could be confirmed in 78.57% of cases (22/27) by demonstration of virus-specific IgM in CSF (151221, viral antigen in CSF (5/2