Particular behavior of ‘C6C2 units’ in the Chichibabin pyridine synthesis and biosynthetic implications

✍ Scribed by Flore Dagorn; Lok-Hang Yan; Edmond Gravel; Karine Leblanc; Alexandre Maciuk; Erwan Poupon

• Book ID: 104099261
• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 580 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2011.05.014

✦ Synopsis

Several aspects of the unusual behavior of C 6 C 2 aldehydes and amines during the formation of pyridiniums in analogy with the historical Chichibabin pyridine synthesis are clarified in this Letter. Interesting biosynthetic consequences are also discussed within two classes of polycyclic alkaloids of marine origin.