Geldanamycin. 3. Biosynthetic origin of the C2 units of geldanamycin and distribution of label from D-[6-13C]glucose
โ Scribed by Haber, Arthur; Johnson, Ronald D.; Rinehart, Kenneth L.
- Book ID
- 127362288
- Publisher
- American Chemical Society
- Year
- 1977
- Tongue
- English
- Weight
- 487 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
A systematic approach, which combines previously reported reactions with appropriate modifications, was established for preparing a variety of selectively deuterated nucleosides from glucoseโข We have developed a systematic method of synthesizing specifically deuterated nucleosides from glucose.
D-(1,5,6-13C3)Glucose (7) has been synthesized by a six-step chemical method. D-(1,2-13C2)Mannose (1) was converted to methyl D-(1,2-13C2)mannopyranosides (2), and 2 was oxidized with Pt-C and O2 to give methyl D-(1,2-13C2)mannopyranuronides (3). After purification by anion-exchange chromatography,
The biosynthetic lncorporatlon of Glucose [U-13C6] into the C7N unit of A23187 indicated that this functionality 1s formed by a divergence of the shlklma e pathway. The z posslblllty that 2,6-dlaminobenzolc acid is a free lntermedlate in the blosynthesls of this unit was ellmlnated.