The therapeutic benefit of G-CSF in the treatment of acute lymphoblastic leukemia has been well established. G-CSF has been used to shorten neutropenia induced by conventional dose cytotoxic chemotherapy and allogeneic bone marrow transplantation. Recently autologous peripheral blood progenitor cell
Participation of granulocyte colony-stimulating factor in the growth regulation of leukemia cells from Philadelphia chromosome-positive acute leukemia and blast crisis of chronic myeloid leukemia
β Scribed by Inukai, T; Sugita, K; Mitsui, K; Iijima, K; Goi, K; Tezuka, T; Kojika, S; Kagami, K; Mori, T; Kinoshita, A
- Book ID
- 110054614
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 161 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0887-6924
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Philadelphia chromosome (Ph')-positive acute lymphoblastic leukemia (ALL) is a malignant disorder characterized by a poor prognosis. In recent years hematopoietic growth factors have been used to recruit myeloid leukemia blasts into the proliferative phase of the cell cycle and as supportive agents,
The use of granulocyte colony-stimulating factor (G-CSF) after chemotherapy for acute myeloblastic leukemia (AML) has been reported. However, there is a drawback in that G-CSF may stimulate the proliferation of AML progenitors. To determine the parameter(s) indicative of responsiveness of AML blasts