✦ LIBER ✦

Partial Synthesis of Grayanotoxin

✍ Scribed by Nobuyuki Hamanaka; Takeshi Matsumoto

Publisher: Elsevier Science
Year: 1972
Tongue: French
Weight: 209 KB
Volume: 13
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)85015-2

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✦ Synopsis

Grayanotoxin (G) II (L)"?

a toxic diterpenoid isolated together with other related grayanoids 1) from Leucothoe grayana Max., is characterized by the A-nor-B-homo-kaurane skeleton and by the dense arrangement of functionality.

We report herein a partial synthesis of G II from a tricyclic degradation product 2, which is in principle synthetically accessible by a number of routes.

The following processes therefore open a way to a relay total synthesis of G II.

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