Quinoline-lactone 7 related to anticancer alkaloid camptothecin has been synthesized from tetrahydroalstonine (2) in four steps through an original rearrangement.
Partial synthesis of camptothecin analogs. Part 1: Pyrroloquinolone and pyrroloquinoline derivatives
✍ Scribed by Cécile Dumas; Christiane Kan-Fan; Jean-François Carniaux; Jacques Royer; Henri-Philippe Husson
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 281 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Pyrroloquinolone 7 and pyrroloquinoline derivatives lla-c have been synthesized from the alkaloid tetrahydroalstonine 1 according to sequential oxidation reactions.
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