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Partial Impairment of Cytokine Responses in Tyk2-Deficient Mice

✍ Scribed by Marina Karaghiosoff; Hans Neubauer; Caroline Lassnig; Pavel Kovarik; Heike Schindler; Hanspeter Pircher; Barbara McCoy; Christian Bogdan; Thomas Decker; Gottfried Brem; Klaus Pfeffer; Mathias Müller

Book ID
117722406
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
620 KB
Volume
13
Category
Article
ISSN
1074-7613

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## Abstract Cathepsin S (CS) is a lysosomal/endosomal cysteine protease especially expressed in cells of a mononuclear lineage including microglia. To better understand the role of CS in microglia, we investigated microglial responses after a facial nerve axotomy in CS‐deficient (CS−/−) and wild‐ty