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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

✍ Scribed by Kaplan, Mark H.; Sun, Ya-Lin; Hoey, Timothy; Grusby, Michael J.

Book ID
109796365
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
1022 KB
Volume
382
Category
Article
ISSN
0028-0836

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## Abstract The cytokine IL‐7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B cell development throughout ontogeny in IL‐7 receptor α‐deficient mice. We demonstrate that the IL‐7 receptor becomes progressively more important with age.