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Partial antagonism of the behavioural and neurochemical effects of phencyclidine by drugs affecting monoamine metabolism

✍ Scribed by Sally R. Tonge; Brian E. Leonard

Publisher: Springer
Year: 1972
Tongue: English
Weight: 269 KB
Volume: 24
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00423442

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✦ Synopsis

Phencyclidine, in common with other hallucinogenic drugs, affects 5-hydroxytryptamine metabolism in the brains of rats. The interactions of pheneyclidine with imipramine and tetrabenazine have been examined. 5-Hydroxytryptamine and 5-hydroxyindoleacetic acid concentrations in three areas of rat brain have been determined after the intraperitoneal administration of pheneyclidine, imipramine and tctrabenazine alone and in combination. A combination of imipramine (5 mg/kg) and tetrabenazine (40 mg/kg) has been found to reverse the effects of phencyelidine on 5-hydroxytryptamine concentrations and to antagonise many of the behavioural effects of the hallucinogen.

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