✦ LIBER ✦

Antagonism by antimuscarinic and ganglion-blocking drugs of some of the behavioural effects of nicotine

✍ Scribed by Cathleen F. Morrison; J. M. Goodyear; C. M. Sellers

Publisher: Springer
Year: 1969
Tongue: English
Weight: 504 KB
Volume: 15
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00403709

No coin nor oath required. For personal study only.

✦ Synopsis

The effects of nicotine on bar-pressing behaviour in the rat are blocked by meeamylamine. The depressant phase of the effect is blocked by atropine, supporting the conclusion that this depression is mediated by released acetylcholine. The quaternary compounds chlorisondamine and atropine methylnitrate also antagonise the behavioural effects of nicotine but the doses required for this are far in excess of those which are effective peripherally, suggesting that the sites of interaction are central.

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