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[Part 2: Biological Sciences] || Correction: N-(6-Aminohexyl)-5-Chloro-l-Naphthalenesulfonamide, a Calmodulin Antagonist, Inhibits Cell Proliferation


Book ID
123623095
Publisher
National Academy of Sciences
Year
1981
Tongue
English
Weight
174 KB
Volume
78
Category
Article
ISSN
0027-8424

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Inhibition of the acrosome reaction of s
โœ Sano, Kiyoshi ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 245 KB

A calmodulin antagonist, W-7 (N-(6-aminohexyl)-5-chloro-l-naphthalenesulfonamide), inhibited induction of the acrosome reaction of sea urchin spermatozoa by egg jelly at 20-50 pM, but W-5 did not. The latter, a chlorine-deficient derivative of W-7, has a lower affinity for calmodulin than does W-7.