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N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, also inhibits phospholipid sensitive calcium-dependent protein kinase

โœ Scribed by Schatzman, Randall C.; Raynor, Robert L.; Kuo, J.F.

Book ID
123247968
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
216 KB
Volume
755
Category
Article
ISSN
0304-4165

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Inhibition of the acrosome reaction of s
Inhibition of the acrosome reaction of sea urchin spermatozoa by a calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7)
โœ Sano, Kiyoshi ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 245 KB

A calmodulin antagonist, W-7 (N-(6-aminohexyl)-5-chloro-l-naphthalenesulfonamide), inhibited induction of the acrosome reaction of sea urchin spermatozoa by egg jelly at 20-50 pM, but W-5 did not. The latter, a chlorine-deficient derivative of W-7, has a lower affinity for calmodulin than does W-7.