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PARP-1-induced cell death through inhibition of the MEK/ERK pathway in MNNG-treated HeLa cells

✍ Scribed by Chantal Éthier; Yves Labelle; Guy G. Poirier

Book ID
106349587
Publisher
Springer
Year
2007
Tongue
English
Weight
654 KB
Volume
12
Category
Article
ISSN
1360-8185

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## Abstract Extracellular signal‐regulated kinase (ERK) 1/2 signaling is involved in tumor cell survival through the regulation of Bcl‐2 family members. To explore this further and to demonstrate the central role of the mitochondria in the ERK1/2 pathway we used the HeLa cellular model where apopto