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Inhibition of the MEK1 and ERK pathway by amlodipine induces vascular smooth muscle cell differentiation in hypertension

✍ Scribed by Seiji Umemoto; Shinji Kawahara; Ryo Hashimoto; Kyoko Umeji; Masunori Matsuzaki

Book ID: 116208833
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 62 KB
Volume: 18
Category: Article
ISSN: 0895-7061
DOI: 10.1016/j.amjhyper.2005.03.207

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## Abstract The process of vascular calcification presents several features similar to osteogenesis in which fibronectin (FN) acts as a regulator of osteoblastic differentiation and the ERK signal pathway is involved. In order to find whether FN promotes the osteoblastic differentiation of vascular