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PARP-1 activation in the ERK signaling pathway

✍ Scribed by Malka Cohen-Armon

Book ID
116918745
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
502 KB
Volume
28
Category
Article
ISSN
0165-6147

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## Abstract We examined the impact of EGFR‐ERK signaling on poly (ADP‐ribose) polymerase (PARP) activation following ionizing irradiation of human prostate cancer (PCa) cell lines displaying marked differences in ERK dependence. PARP activation was indicated by the appearance of polyADP‐ribose, the