Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired chronic hemolytic anemia associated with an unusual susceptibility to hemolytic crisis, infection, and venous thrombosis which would be aggravated by a number of factors including surgery. We report a case of PNH undergoing percutaneous transl
Paroxysmal nocturnal hemoglobinuria clone in patients with myelodysplastic syndrome
✍ Scribed by Mustafa N. Yenerel; Reyhan Diz-Kucukkaya; Sevgi Besisik; Melih Aktan; Meliha Nalcaci; Günçag Dincol; Abdullah Hacihanefioglu; Mehmet Turgut
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 199 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0361-8609
- DOI
- 10.1002/ajh.1154
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A patient with paroxysmal nocturnal hemoglobinuria developed lactic acidosis associated with severe anemia. The lactic acidosis corrected after blood transfusion. In the absence of shock, sepsis, or other identifiable causes of lactic acidosis, the severe anemia (hemoglobin 1.2 g/dl) appeared to be
## Abstract We describe a 52‐year‐old man with paroxysmal nocturnal hemoglobinuria (PNH) and a moderate transfusion requirement. Prior to and during sequential therapy with androgen (metenolone), glucocorticoid, and danazol, we evaluated CD59‐negative expression (PNH clone) in red blood cells, neut
## Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a debilitating and life‐threatening disease in which lysis of PNH red blood cells frequently manifests with chronic hemolysis, anemia, and thrombosis. Renal damage in PNH is associated with chronic hemosiderosis and/or microvascular thrombosi