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Paroxysmal dyskinesias in mice

โœ Scribed by Thomas L. Shirley; Lekha M. Rao; Ellen J. Hess; H. A. Jinnah

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
139 KB
Volume
23
Category
Article
ISSN
0885-3185

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โœฆ Synopsis

Abstract

Animal models of human disease are important tools for revealing the underlying mechanisms of pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that are phenotypically similar to human paroxysmal dyskinesias. In this report, video demonstrations of these motor attacks are provided for two previously described mouse mutants, tottering and lethargic, as well as a new one, rocker. Semiquantitative comparisons using two different rating scales reveal differences in attack morphology, severity, and duration among the strains. These mice provide three independent models of paroxysmal dyskinesia and support for prior proposals that channelopathies may underlie the human disorders. ยฉ 2007 Movement Disorder Society

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