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Parkinson's disease/Parkinson syndromes—therapy: Miscellaneous


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
210 KB
Volume
7
Category
Article
ISSN
0885-3185

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✦ Synopsis


r i e d m a n , B r o w n U n i v e r s i t y , P r o v i d e n c e , R h o d e I s l a n d , C. C a l e y , I n s t i t u t e f o r m e n t a l H e a l t h , C r a n s t o n , R h o d e I s l a n d W e r e v i e w e d our e x p e r i e n c e w i t h f l u o x e t i n e in i d i o p a t h i c P a r k i n s o n ' s d i s e a s e ( I P D ) . 23 p a t i e n t s w i t h I P D r e c e i v e d f l u o x e t i n e . D o s e s o f 10-40mg d a i l y w e r e u s e d . O n e of 4 a l s o t a k i n g d e p r e n y l d e v e l o p e d m a r k e d w o r s e n i g n o f b a s e l i n e a

k a t h i s i a w h i c h r e s o l v e d w i t h f l u o x e t i n e w i t hd r a w a l . T h e o t h e r d e p r e n y l t r e a t e d p a t i e n t s h a v

e h a d n o a d v e r s e e f f e c t s . O f t h e 1 9 n o t t a k i n g d e p r e n y l 3 s u f f e r e d s i d e e f f e c t s r e q u i r i n g f l u o x e t i n e w i t h d r a w a l , o n e d u e t o s o m n o l e n c e a n d 2 d u e t o c o n f u s i o n . F l u o x e t i n e w a s n o t f o u n d t o w o r s e n p a r k i n s o n i s m in a n y c a s e . W e c o n c l u d e t h a t f l u o x e t i n e , in d o s e s u p t o 4 0 m g d a i l y d o e s n o t w o r s e n PD a n d c a n p r o b a b l y b e u s e d s a f e l y in c o nj u n c t i o n w i t h d e p r e n y l .


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