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Parental centromere separation sequence and aneuploidy in the offspring

✍ Scribed by Katalin Bajnóczky; K. Méhes

Book ID
104707561
Publisher
Springer
Year
1988
Tongue
English
Weight
183 KB
Volume
78
Category
Article
ISSN
0340-6717

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✦ Synopsis

We have studied the centromere separation sequence in lymphocyte mitoses of the parents of four infants with trisomy 18, five patients with trisomy 21, and five children with normal karyotype. "Late separation" of chromosome 18 was found in both parents of a neonate with trisomy 18, "early separation" of chromosome 21 in three mothers and in one father of four children with trisomy 21. No "out-of-phase" separation occurred in the mitoses of the parents of normal children. The findings provide further evidence for the correlation between alteration of the parental centromere separation sequence and aneuploidy of the offspring.

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The effect of cyclophosphamide on the centromere separation sequence in Chinese hamster spermatogonia
✍ Jai Rup Singh; Herbert G. Miltenburger 📂 Article 📅 1977 🏛 Springer 🌐 English ⚖ 224 KB

The sequence of centromere separation in spermatogonial chromosomes of untreated and cyclophosphamide-treated Chinese hamsters is described. Centromeres of chromosome 1 and 2 separated much earlier than all other chromosomes, especially 6-8. Cyclophosphamide significantly inhibits the centromere sep