Tissues from a range of fish were examined for the presence of parathyroid hormone-related protein (PTHrP) to investigate PTHrP protein distribution and PTHrP gene expression in jawless fish, cartilaginous fish, and bony fish. Immunoreactive PTHrP was localized using antisera to N-terminal and mid-m
Parathyroid hormone-related protein (PTHrP) and blood pressure
β Scribed by Takeshi Kiriyama; Kaoru Fujiyama; Shoichi Nagao; Shinji Seto; Naokata Yokoyama; Shigenobu Nagataki
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 355 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0914-8779
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The N-terminal 1-34 segments of both parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) bind and activate the same membrane-embedded G protein-coupled receptor (PTH1 Rc) present on the surface of cells in target tissues such as bone and kidney. This binding occurs in spite of
The N-terminal 1-34 segments of both parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) bind and activate the same membrane receptor in spite of major differences between the two hormones in their amino acid sequence. Recently, it was shown that in (1-34)PTH/PTHrP segmental hy