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Parathyroid Hormone Induces Mitogen-Activated Kinase Phosphatase 1 in Murine Osteoblasts Primarily Through cAMP-Protein Kinase A Signaling

✍ Scribed by Aghaloo, Tara L.; Pirih, Flavia Q.; Shi, Andrew; Bezouglaia, Olga; Tetradis, Sotirios

Book ID
127309728
Publisher
American Academy of Periodontology
Year
2006
Tongue
English
Weight
424 KB
Volume
77
Category
Article
ISSN
0022-3492

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## Abstract Parathyroid hormone (PTH) regulation of mitogen‐activated protein kinases (MAPK) ERK1/2 contributes to PTH regulation of osteoblast growth and apoptosis. We investigated the mechanisms by which PTH inhibits ERK1/2 activity in osteoblastic UMR 106‐01 cells. Treatment with PTH significant