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Identification and activation of mitogen-activated protein (MAP) kinase in normal human osteoblastic and bone marrow stromal cells: Attenuation of MAP kinase activation by cAMP, parathyroid hormone and forskolin

✍ Scribed by Lala R. Chaudhary; Louis V. Avioli


Book ID
110241509
Publisher
Springer
Year
1998
Tongue
English
Weight
348 KB
Volume
178
Category
Article
ISSN
0300-8177

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## Abstract Parathyroid hormone (PTH) regulation of mitogen‐activated protein kinases (MAPK) ERK1/2 contributes to PTH regulation of osteoblast growth and apoptosis. We investigated the mechanisms by which PTH inhibits ERK1/2 activity in osteoblastic UMR 106‐01 cells. Treatment with PTH significant