Parathyroid Hormone and 1,25-Dihydroxyvitamin D Synergistically Induce the 1,25-Dihydroxyvitamin D-24-Hydroxylase in Rat UMR-106 Osteoblast-like Cells
โ Scribed by H.J. Armbrecht; T.L. Hodam
- Book ID
- 115575744
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 349 KB
- Volume
- 205
- Category
- Article
- ISSN
- 0006-291X
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## Abstract The 25โhydroxyvitamin D~3~โ24โhydroxylase mRNA is tightly and reciprocally regulated by 1,25โdihydroxyvitamin D~3~ (1,25(OH)~2~D~3~) and parathyroid hormone (PTH). The upregulation of the 24โhydroxylase by 1,25(OH)~2~D~3~ is well established and occurs at the transcriptional level throu
## Abstract 1,25โDihydroxyvitamin D~3~ (1,25(OH)~2~D~3~) treatment of osteoblastic cells was shown previously to attenuate Parathyroid hormone (PTH) response by inhibiting adenylyl cyclase (AC) activity. In this study, we have investigated the mechanism by which 1,25(OH)~2~D~3~ inhibits AC in rat o